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PubMed COVID-19 Clinical Care

2001 - 2010 of 3573 results found

Evolutionary safety of lethal mutagenesis driven by antiviral treatment

Date
Tuesday, August 08, 2023 - 4:00 AM
Description
Nucleoside analogs are a major class of antiviral drugs. Some act by increasing the viral mutation rate causing lethal mutagenesis of the virus. Their mutagenic capacity, however, may lead to an evolutionary safety concern. We define evolutionary