HLA-DPB1*013:01 associates with enhanced, and KIR2DS4*001 with diminished protection from developing severe COVID-19
Description
Extreme polymorphism of HLA and killer-cell immunoglobulin-like receptors (KIR) differentiates immune responses across individuals. Additional to T cell receptor interactions, subsets of HLA class I act as ligands for inhibitory and activating KIR
