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PubMed COVID-19 Clinical Care

13081 - 13090 of 44979 results found

Molecular Design of Novel Inhibitor by TargetingIL-6Rα using Combined Pharmacophore and Experimentally Verified Plant Products with Scaffold-Hopping Techniques: A Dual Therapeutic Strategy for COVID-19 and Cancer

Date
Wednesday, November 15, 2023 - 4:00 AM
Description
The IL-6/IL-6R/gp130 complex serves as a significant indicator of cytokine release syndrome in COVID-19 and chronic inflammation, increasing the risk of cancer. Therefore, we identified IL-6Rα as a potential target to block gp130 interaction. Notably

Colloidal aggregation confounds cell-based Covid-19 antiviral screens

Date
Tuesday, November 14, 2023 - 4:00 AM
Description
Colloidal aggregation is one of the largest contributors to false-positives in early drug discovery and chemical biology. Much work has focused on its impact on pure-protein screens; here we consider aggregations role in cell-based infectivity assays